The expedition opened up new territory for the fur and lumber trade and pointed out the best lands for future settlement and agriculture. It allowed a young country to blossom into greatness, because more land had equated to more resources and therefore, more power. The influence of the expedition is incalculable.Click to see full answer. Simply so, how did the Lewis and Clark expedition affect Manifest Destiny?This expedition furthered American ideology of manifest destiny because Americans believed it was their duty from God. However, throughout their journey they encountered Native Americans which would greatly influence American culture and ideals in the years to come.Similarly, was Lewis and Clark’s expedition successful? Answer and Explanation: The Lewis and Clark expedition was successful. The expedition set out on May 14, 1804, and made it to the Pacific Ocean in November of 1805. Moreover, what did Lewis and Clark do on their expedition? Lewis and Clark Expedition, (1804–06), U.S. military expedition, led by Capt. Meriwether Lewis and Lieut. William Clark, to explore the Louisiana Purchase and the Pacific Northwest. The expedition was a major chapter in the history of American exploration.Why are Lewis and Clark important to American history? The Lewis And Clark Expedition Begins Their mission was to explore the unknown territory, establish trade with the Natives and affirm the sovereignty of the United States in the region. One of their goals was to find a waterway from the US to the Pacific Ocean.