Can rifampin and warfarin be taken together?
The drug interaction between warfarin and rifampin is not well known. Rifampin has been reported to increase the warfarin requirements in human subjects ingesting these agents simultaneously. This effect may be mediated by the ability of rifampin to induce microsomal enzymes and, thus, the catabolism of warfarin.Click to see full answer. Also to know is,…
The drug interaction between warfarin and rifampin is not well known. Rifampin has been reported to increase the warfarin requirements in human subjects ingesting these agents simultaneously. This effect may be mediated by the ability of rifampin to induce microsomal enzymes and, thus, the catabolism of warfarin.Click to see full answer. Also to know is, does rifampin increase INR?2013). This interaction affects warfarin dose required to achieve and maintain therapeutic INR and may increase this dose up to six times to reach target therapeutic INR. This interaction remains clinically significant during, and weeks after discontinuation of rifampin.Secondly, can you take metroNIDAZOLE with warfarin? Using warfarin together with metroNIDAZOLE may cause you to bleed more easily. You may need a dose adjustment based on your prothrombin time or International Normalized Ratio (INR). Considering this, what drugs are contraindicated with warfarin? Specific antiplatelet agents that could interact with warfarin include aspirin, clopidogrel (Plavix), ticlopidine, and dipyridamole (Aggrenox, Persantine).How does cimetidine affect warfarin?Cimetidine potentiates the anticoagulant effect of warfarin sodium, but in one small study ranitidine hydrochloride did not. Substituted imidazoles like cimetidine inhibit hepatic microsomal activity, which may cause reduced metabolic clearance of warfarin and augment its anticoagulant effect.
