How does tautomeric shifts lead to mutations?
tautomeric shift definition. The spontaneous isomerization of a nitrogen base to an alternative hydrogen-bonding form, possibly resulting in a mutation. Reversible shifts of proton position in a molecule. Bases in nucleic acids shift between keto and enol forms or between amino and imino forms.Click to see full answer. Thereof, what is Tautomeric shift how may…
tautomeric shift definition. The spontaneous isomerization of a nitrogen base to an alternative hydrogen-bonding form, possibly resulting in a mutation. Reversible shifts of proton position in a molecule. Bases in nucleic acids shift between keto and enol forms or between amino and imino forms.Click to see full answer. Thereof, what is Tautomeric shift how may it lead to a mutation?Tautomeric shift is an intramolecular electron shift that changes the bonding structure of the molecule. How may it lead to a mutation? It allows hydrogen bonding of normally noncomplementary bases. It allows deletion of one or more bases in the template strand of DNA.Subsequently, question is, what is the cause of spontaneous mutation? A common cause of spontaneous point mutations is the deamination of cytosine to uracil in the DNA double helix. Another cause of spontaneous mutations is copying errors during DNA replication. Although replication generally is carried out with high fidelity, errors occasionally occur. In respect to this, when might a mutation occur spontaneously? In addition to replication errors, spontaneous lesions, naturally occurring damage to the DNA, can generate mutations. Two of the most frequent spontaneous lesions result from depurination and deamination.Are tautomeric shifts transient?A tautomeric shift in one strand has produced a transition mutation in the complementary strand. If the mutation occurs in the germline, it will be transmitted to future generations. IMPORTANT: Note that a tautomeric shift is not itself a mutation, but a transient change to an alternative form of the molecule.
