What is the role of Shh in limb development?
Shh has also been shown to control the width of the limb bud by stimulating mesenchyme cell proliferation and by regulating the antero-posterior length of the apical ectodermal ridge, the signaling region required for limb bud outgrowth and the laying down of structures along the proximo-distal axis (e.g., shoulder toClick to see full answer. Correspondingly,…
Shh has also been shown to control the width of the limb bud by stimulating mesenchyme cell proliferation and by regulating the antero-posterior length of the apical ectodermal ridge, the signaling region required for limb bud outgrowth and the laying down of structures along the proximo-distal axis (e.g., shoulder toClick to see full answer. Correspondingly, when and how do the limbs develop?A. Much of the initial growth and patterning of the limbs occurs during weeks 4 – 8. Limb buds appear at about 4 weeks and much of the basic structures of the limbs (bones and muscle groups) are established by 8 weeks. After 8 weeks, the limb elements then just increase in size. how do limbs develop? Through such studies, researchers have observed that limbs form initially from buds that appear along the sides of the developing body. The buds consist of a “jacket” of outer cells, or ectoderm, surrounding a core of other cells called the mesoderm. Consequently, how does Shh work? SHH plays a very important role in organogenesis and most importantly craniofacial development. Being that SHH is a signaling molecule it primarily works by diffusion along a concentration gradient affecting cells in different manners. However SHH activates downstream molecules of Gli2 & Gli3.What type of protein is Sonic hedgehog?The SHH gene provides instructions for making a protein called Sonic Hedgehog. This protein functions as a chemical signal that is essential for embryonic development. Sonic Hedgehog plays a role in cell growth, cell specialization, and the normal shaping (patterning) of the body.
