Why are tricyclic antidepressants so toxic in overdose?
Tricyclic antidepressant overdose is poisoning caused by excessive medication of the tricyclic antidepressant (TCA) type. Symptoms may include elevated body temperature, blurred vision, dilated pupils, sleepiness, confusion, seizures, rapid heart rate, and cardiac arrest. The toxic dose depends on the specific TCA.Click to see full answer. Also question is, how do the tricyclics cause their…
Tricyclic antidepressant overdose is poisoning caused by excessive medication of the tricyclic antidepressant (TCA) type. Symptoms may include elevated body temperature, blurred vision, dilated pupils, sleepiness, confusion, seizures, rapid heart rate, and cardiac arrest. The toxic dose depends on the specific TCA.Click to see full answer. Also question is, how do the tricyclics cause their toxicity?Tricyclic antidepressants (TCA) are one of the common causes of a fatal drug overdose. Tricyclic Antidepressants have their toxic effects through action at 4 main receptors involving antagonism/inhibition at: Central and peripheral acetylcholine receptors. α adrenergic receptors peripherally.Likewise, how much amitriptyline is toxic? The maximum daily dose for adults is 300 milligrams. Overdose of amitriptyline or other tricyclic antidepressants can be fatal. The following signs and symptoms indicate a serious overdose requiring urgent medical attention: irregular heartbeat. Consequently, why does TCA overdose cause acidosis? The amount of unbound tricyclic may also increase if the over- dose causes respiratory depression resulting in an acidosis, which reduces protein binding. The toxic eVects of tricyclics are caused by four main pharmacological properties: 1 Inhibition of norepinephrine reuptake at nerve terminals.Which Antidysrhythmic is most appropriate for treating ventricular dysrhythmias caused by tricyclic antidepressant toxicity?Furthermore, the sodium load itself may help to overcome the toxicity due to sodium channel blockade. NaHCO3 has been demonstrated to be superior to antidysrhythmics for the treatment of TCA induced ventricular dysrhythmias. They are best treated with benzodiazepines, barbituates, and alkalinization with NaHCO3.
